4.8/5 based on 14,234+ customers

Everleaf Nattokinase Complex

Supports healthy circulation and arterial function — on both fronts, every day.

Works on the inflammation that keeps the cycle running

Three enzymes on the fibrous tissue already deposited

Supports circulation you can feel — hands and feet included

Formulated for healthy blood flow and arterial function

CoQ10 for cellular energy in the heart muscle

Both fronts at once — the deposit and the stimulus

VIEW PRODUCT

60-Day Money Back Guarantee

Try it for two full months. If you're not satisfied, contact us for 100% of your money back. No questions asked.

What's Inside

Nattokinase 500 mg (10,000 FU) · Bromelain 140 mg (2,400 GDU/g) · Serrapeptase 120 mg (18,000 SPU) · Curcumin 100 mg · CoQ10 100 mg · Ginger 50 mg · Olive Leaf Extract 15 mg · White Willow Bark 10 mg · Black Pepper Extract 5 mg. In an MCT oil base. No soy, no artificial colors.

60-Day Guarantee

Take Everleaf for two full months. If you're not satisfied, for any reason at all, contact us for a full refund. Empty bottles are fine. No forms, no return shipping, no explanation required.

Description

Everleaf Nattokinase Complex is a nine-active softgel formulated around two fronts: three proteolytic enzymes working on fibrous tissue already deposited in the artery wall, and five actives working on the inflammation that keeps depositing it. Three softgel daily, taken with food.

Real People. Real Numbers.

★★★★★ Rated 4.8 / 5.0 · 'Excellent'
Wayne K., verified Everleaf customer

"My cardiologist asked what I'd changed"

★★★★★ 5.0

I'm 63. Four miles a day, gave up red meat in 2019, and my calcium score still went 240 to 311 in three years. Every appointment was the same conversation. Eat well. Keep exercising. We'll watch it.

Nobody ever told me the plaque was tissue my own body was building. That changed how I thought about the whole thing.

Month four now. Last panel was the first one in six years that didn't go the wrong way. My cardiologist asked what I'd changed, and for once I had an answer.

— Wayne K., 63 · Verified Customer
Craig N., verified Everleaf customer

"I stopped dreading the appointment"

★★★★★ 5.0

Every six months I'd sit in that waiting room doing the math on what the number would be. My wife stopped asking how it went. She could tell from my face.

Started in February. Around week six my feet weren't cold at night anymore. Small thing. But it was the first thing I could actually feel.

Went in for bloodwork in June and left without that knot in my stomach. First time in years.

— Craig N., 58 · Verified Customer
Russell M., verified Everleaf customer

"Finally something that explained the why"

★★★★★ 5.0

Fish oil, red yeast rice, garlic, CoQ10. Every bottle said "supports cardiovascular health" and not one told me what was actually happening in there.

This was the first label where I could point at each ingredient and say what it's for. Nine ingredients, nine jobs.

Three months in, my energy is better and my numbers moved for the first time. I only wish I'd found it sooner.

— Russell M., 67 · Verified Customer
Darlene V., verified Everleaf customer

"My husband's not a supplement guy"

★★★★★ 5.0

He rolls his eyes at anything that isn't prescribed. But his last appointment went badly and he was willing to try something.

Ten weeks consistent, which for him is a record. He says his hands don't go numb on the golf course anymore.

Last week he ordered the six-pack himself. I didn't say a word.

— Darlene V., 61 · Verified Customer
Glenn R., verified Everleaf customer

"I read the study before I bought"

★★★★★ 5.0

I'm the guy who reads the fine print. Looked up the trial they reference — 1,062 people, twelve months. They're upfront that it's a study on the enzyme, not on their bottle. I respected that.

Since March. Ninety days in, my LDL and my inflammation marker both moved in the right direction — which is more than the last four things I tried managed to do.

— Glenn R., 60 · Verified Customer
Medical cross-section illustration of an artery wall with fibrous tissue

The Reason Your Number Keeps Climbing Is Not What You Were Told

The plaque on your scan didn't float in through your bloodstream. Your body built it. The artery wall takes small injuries constantly, and every time it does, your body deposits fibrin to seal them shut. That's repair. It's supposed to happen. It's supposed to finish.

Chronic inflammation is what keeps the cycle switched on. The repair never closes, each new layer of fibrous tissue traps cholesterol and calcium on its way down, and the number climbs — not because you weren't disciplined, but because a process that should have ended years ago is still running.

  • A calcium score that keeps rising despite a clean diet and daily exercise
  • Bloodwork you brace yourself for every six months
  • Appointments that end with "keep doing what you're doing" and nothing else
  • The sense that you're tracking a number instead of doing something about it
Cardiologists have a term for the underlying process: arterial remodeling. When inflammation keeps it permanently active, the repair never closes. We call that Persistent Arterial Remodeling — and it's the reason the deposit keeps rebuilding.

There Are Two Things Happening in Your Artery. Most Formulas Address One.

The Deposit

The fibrous tissue already sitting in the artery wall. Work on it alone, and the stimulus keeps rebuilding it.

The Stimulus

The chronic inflammation keeping the repair cycle open. Work on it alone, and the existing deposit stays where it is.

Both fronts, or the cycle continues.
That's what the Tri-Enzyme Protocol was built around.
The Tri-Enzyme Protocol™

Nine Actives. Two Fronts. Nothing in the Bottle Without a Job.

Everleaf was formulated around the distinction above — one group of actives for the tissue already deposited, another for the inflammation that keeps depositing it.

Front One

Three enzymes on what's already there
Natto fermented soybeans, the source of nattokinase

Nattokinase

500 mg · 10,000 FU

Works on fibrin — the protein your body uses to seal each injury, and the protein that traps everything else as it hardens. This is the enzyme with the deepest research behind it, and we deliver it in the range of the clinical reference dose rather than a fraction of it.

Serrapeptase enzyme, macro product photography

Serrapeptase

120 mg · 18,000 SPU

A second proteolytic enzyme with a different substrate profile. Fibrous tissue isn't built from one protein, and enzymes don't work on proteins they don't fit. A second enzyme reaches what the first one doesn't.

Fresh pineapple, the source of bromelain

Bromelain

140 mg · 2,400 GDU/g

The third protease, widening the range further. Three enzymes working in cascade cover a span of protein substrate that no single enzyme reaches at any dose.

Front Two

Five actives on the stimulus
Turmeric root and black peppercorns

Curcumin + Black Pepper

100 mg + 5 mg

The central anti-inflammatory active in the formula, paired with piperine — the best-documented absorption pairing in supplementation. Curcumin on its own is largely a nice color. With piperine, it's an ingredient.

Fresh ginger root

Ginger

50 mg

A second anti-inflammatory pathway, distinct from curcumin's. Traditional use, modern research, and no acquired taste required.

White willow bark

White Willow Bark

10 mg

The botanical source of salicin — the compound that eventually became aspirin, and the reason this plant has a place in a cardiovascular formula.

Olive leaves and branch

Olive Leaf Extract

15 mg

The Mediterranean axis, concentrated. The dietary pattern with the deepest cardiovascular literature behind it, in a form that isn't a lifestyle change.

CoQ10 softgels, macro product photography

CoQ10

100 mg

Cellular energy for heart muscle — the tissue with the highest energy demand in your body. If you're on a statin, you may already have this bottle on your shelf.

Everleaf softgel in MCT oil base

Delivered in MCT oil

One softgel daily

The oil base means no empty-stomach window and no fasting schedule to plan around. You take it with a meal, the way you already take everything else.

Nine actives. Nine defined roles. Nothing added to make the label longer.

What You Feel First, and What Comes After

Weeks 1–2
Building Up

The enzymes reach working levels and the anti-inflammatory actives begin to accumulate. Most people feel nothing yet. That's expected — and it's exactly why this is sold in cycles rather than single bottles.

  • Daily protocol established
  • Nothing to report, which is normal

This is where most people notice peripheral circulation — warmer hands and feet, less numbness after sitting a while. It's the earliest signal your body gives you, and it shows up long before anything shows up on paper.

  • Warmer hands and feet, most commonly reported
  • Steadier energy through the afternoon
Weeks 3–6
The First Thing You Feel
Weeks 7–12
The Full Cycle

Both fronts have now been working together for a complete cycle. This is the window where retesting makes sense, and most people schedule bloodwork around day 90 for that reason.

  • One full protocol cycle complete
  • The right moment to look at your numbers again

Arterial remodeling is a continuous process, not an event. Ongoing support is the entire point — which is why the 6-bottle and the subscription are priced the way they are.

  • Continued support on both fronts
  • Consistency is the variable that matters most
Month 4+
Ongoing Support
Why Everleaf?

What a Two-Front Formula Looks Like

  Everleaf Single-Enzyme Formulas
Proteolytic enzymesThreeOne
Anti-inflammatory activesFive
Nattokinase dose10,000 FUVaries
Works on the deposit
Works on the stimulus
Third-party tested every batchVaries
Take with food, no fasting windowVaries
60-day money back guaranteeVaries
Recommended by Specialists

"The formulation reflects how we actually think about arterial health."

Most of what reaches my patients works on one thing at a time. What stands out here is that the deposit and the inflammatory side are addressed together, at doses that match what the literature actually studied.

I tell patients that supplementation supports the work — it doesn't replace the appointment, the panel, or the medication. Within that, this is a formula I'm comfortable seeing on a nightstand.

Dr. Nathaniel Brandt, MD
Board-Certified Cardiologist · 22 years in preventive cardiology
Dr. Nathaniel Brandt, board-certified cardiologist
60-day money back guarantee badge
Risk-Free

Take It for Two Full Months. On Us.

Start your first cycle. Take one softgel a day, with a meal, and give it the time the protocol asks for.

If you're not satisfied — for any reason at all — contact us within 60 days for a full refund. Send back the empty bottles if you like.

No forms. No return shipping. No explanation required.

Two months is enough time to know whether this belongs in your routine. If it doesn't, you shouldn't be paying for it.

Reviews

What Customers Say

4.8
out of 5.0
★★★★★
Based on 14,234+ reviews
5 star 91%
4 star 6%
3 star 1%
2 star 1%
1 star 1%
★★★★★

One a day with breakfast and I'm done. The last enzyme I took wanted an empty stomach and I kept forgetting it. This one I actually remember.

Duane H. · Verified Purchase
★★★★★

Lined this up against three other bottles on my shelf. Only one where I could account for every ingredient on the label. That told me more than the marketing did.

Curtis B. · Verified Purchase
★★★★★

Skeptical about the circulation part until it happened. Week five, sitting on the couch, realized my feet were warm. Sounds like nothing. Wasn't nothing to me.

Vern L. · Verified Purchase
★★★★★

Started with one bottle to see. Ninety days later I ordered six. My wife takes it now too. That's the whole review.

Marvin S. · Verified Purchase
★★★★★

Take it with breakfast and never think about it again. No aftertaste, no repeating on me the way fish oil always did.

Roger T. · Verified Purchase
★★★★★

Brought the bottle to my appointment since I'm on other medication. He read the label, said it was fine alongside what I take, and told me to keep him posted. Appreciated being able to just hand it over.

Dale F. · Verified Purchase
★★★★★

Month two. Energy through the afternoon is steadier than it was and I'm not crashing at three o'clock. Retesting in November and I'll update then.

Neil C. · Verified Purchase
★★★★★

Most bottles say "supports cardiovascular health" and stop there. This one tells you which ingredient does what. I shouldn't have to research a supplement to understand it.

Warren G. · Verified Purchase
★★★★★

Right on schedule with what the page said. Warmer hands, steadier through the day. Ordered the three pack after that.

Clifford J. · Verified Purchase
Load More Reviews
Frequently Asked Questions

Everything You Want to Know Before You Order

How do I take it?
One softgel a day, with a meal. That's the entire protocol. The oil base means no empty-stomach window and no fasting schedule to plan around.
Can I take this alongside my medication?
Talk to your doctor first — particularly if you take a blood thinner or an antiplatelet, or if you have surgery scheduled. Proteolytic enzymes are worth mentioning to your physician. We'd rather you have that conversation than skip it.
When will I notice anything?
Circulation usually comes first — warmer hands and feet, somewhere around weeks three to six. What's happening in the artery wall takes longer than what you can feel. Give it a full 90-day cycle before you judge it.
Is 10,000 FU enough? I've seen higher numbers.
FU measures one enzyme's activity on one protein. It's the right ruler for a one-ingredient product. There's no single unit that measures what three enzymes and five actives do together. 10,000 FU puts you in the range of the clinical reference dose, which is the number that matters.
How is this different from the nattokinase I already take?
Yours works on fibrin, and fibrin is one component of the tissue rather than all of it. Everleaf adds two more enzymes with different substrate profiles, plus five actives working on the inflammatory side. It's not that your bottle was doing nothing. It was working one front.
What if it doesn't do anything for me?
Then you email us and we refund you. You have 60 full days. Empty bottles are fine, and there's no form to fill out and no return shipping to pay. Two months is enough time to know whether this is doing something for you. If it isn't, you shouldn't be paying for it.